To reduce the development of drug-resistant bacteria and maintain the effectiveness of zithromax (azithromycin) and other bacterial drugs, zithromax (azithromycin) should be used only to zithromax for strep treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Description, zithromax (azithromycin tablets zithromax 250mg dosage and azithromycin zithromax 250mg dosage for oral suspension) contain the active ingredient azithromycin, an azalide, a subclass of macrolide antibiotics, for oral administration. Azithromycin has the chemical name ( 2R,3S,4R,5R,8R, 10R,11R,12S,13S,14R )- 13-(2,6-dideoxy-3-, c -methyl-3-, o -methyl-(alpha)-, l-ribo d-xylo Azithromycin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C 38 H 72 N 2 O 12, and its molecular weight is 749.00. Azithromycin has the following structural formula: Azithromycin, as the dihydrate, is a white crystalline powder with generic zithromax azithromycin a molecular formula of C 38 H 72 N 2 O 12 2H 2 O and a molecular weight of 785.0. Zithromax is supplied for oral administration as film-coated, modified capsular shaped tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium generic zithromax azithromycin stearate, sodium lauryl sulfate, hypromellose, lactose, titanium. Zithromax for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD C Red #40; and. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin. Pharmacokinetics, following oral administration of a single 500 mg dose (two 250 mg tablets) to 36 fasted healthy male volunteers, the mean (SD) pharmacokinetic parameters were AUC 0-72.3 (1.2) gh/mL; C max.5 (0.2) g/mL; T max.2 (0.9) hours. With a regimen uti zithromax of 500 mg (two 250 mg capsules * ) on day zithromax 250mg dosage 1, followed by 250 mg daily (one 250 mg capsule) on days 2 through 5, the pharmacokinetic parameters of azithromycin in plasma in healthy young adults (18-40 years of age) are. C min and C max remained essentially unchanged from day 2 through day 5 of therapy. Pharmacokinetic Parameters (Mean total n12, day. Day 5, c max (g/mL).41.24, t max (h).5.2, aUC 0-24 (gh/mL).6.1, c min (g/mL).05.05, urinary Excret. ( dose).5.5 *Azithromycin 250 mg tablets are bioequivalent to 250 mg capsules in the fasted state. Azithromycin 250 mg capsules are no longer commercially available. In a two-way crossover study, 12 adult healthy volunteers (6 males, 6 females) received 1,500 mg of azithromycin administered in single daily doses over either 5 days (two 250 mg tablets on day 1, followed by one 250 mg tablet on days 2-5). Due to limited serum samples on day 2 (3-day regimen) and days 2-4 (5-day regimen the serum concentration-time profile of each subject was fit to a 3-compartment model and the AUC 0-(infinity) for the fitted concentration profile was comparable between the 5-day and 3-day regimens. Pharmackoinetic Parameter mean (SD) 3-Day Regimen 5-Day Regimen. Day 3, day. Day 5 C max (serum, g/mL).44 (0.22).54 (0.25).43 (0.20).24 (0.06) Serum AUC 0-(infinity) (ghr/mL).4 (6.2) *.9 (3.1) * Serum.8.9 hr *Total AUC for the entire 3-day and 5-day regimens Median azithromycin exposure (AUC 0-288 ). Administration of the same total dose with either the 5-day or 3-day regimen may be expected to provide comparable concentrations of azithromycin within MN and PMN leukocytes. Two azithromycin 250 mg tablets are bioequivalent to a single 500 mg tablet. Absorption The absolute bioavailability of azithromycin 250 mg capsules. In a two-way crossover study in which 12 healthy subjects received a single 500 mg dose of azithromycin (two 250 mg tablets) with or without a high fat meal, food was shown to increase C max by 23 but had no effect on AUC. When azithromycin suspension was administered with food to 28 adult healthy male subjects, C max increased by 56 and AUC was unchanged. The AUC of azithromycin was unaffected by co-administration of an antacid containing aluminum and magnesium hydroxide with azithromycin capsules; however, the C max was reduced. Administration of cimetidine (800 mg) two hours prior to azithromycin had no effect on azithromycin absorption. Distribution The serum protein binding of azithromycin is variable in the concentration range approximating human exposure, decreasing from 51.02 g/mL to 7 at 2 g/mL. Following oral administration, azithromycin is widely distributed throughout the body with an apparent steady-state volume of distribution.1 L/kg. Greater azithromycin concentrations in tissues than in plasma or serum were observed. High tissue concentrations should not be interpreted to be quantitatively related to clinical efficacy. The antimicrobial activity of azithromycin is pH related and appears to be reduced with decreasing. However, the extensive distribution of drug to tissues may be relevant to clinical activity. Selected tissue (or fluid) concentration and tissue (or fluid) to plasma/serum concentration ratios are shown in the following table: azithromycin concentrations following A 500 mg dose (TWO 250 mg capsules) IN adults 1 tissue OR fluid time after dose (h) tissue OR fluid concentration (g/g. Sample was obtained 2-4 hours after the first zithromax 250mg dosage dose. Sample was obtained 10-12 hours after the first dose. Dosing regimen of two doses of 250 mg each, separated by 12 hours. Sample was obtained 19 hours after a single 500 mg dose. The extensive tissue distribution was confirmed by examination of additional tissues and fluids (bone, ejaculum, prostate, ovary, uterus, salpinx, stomach, liver, and gallbladder). As there are no data from adequate and well-controlled studies of azithromycin treatment of infections in these additional body sites, the clinical importance of these tissue concentration data is unknown. Following a regimen of 500 mg on the first day and 250 mg daily for 4 days, only very low concentrations were noted in cerebrospinal fluid (less than.01 g/mL) in the presence of non-inflamed meninges. Metabolism In vitro and in vivo studies to assess the metabolism of azithromycin have not been performed. Elimination Plasma concentrations of azithromycin following single 500 mg oral and.v. Doses declined in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min and terminal elimination half-life of 68 hours. The prolonged terminal half-life is thought uti zithromax to be due to extensive uptake and subsequent release of drug from tissues.
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Generic Name: azithromycin (a zith roe zithromax chlamydia dose MYE sin brand Names: Zithromax, Zmax, medically reviewed on September 29, 2017. Zithromax (azithromycin) is an antibiotic that fights bacteria. Zithromax is used to treat zithromax chlamydia dose many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. Zithromax may also be used for purposes not listed in this medication guide. You should not use Zithromax if you have ever had jaundice or liver problems caused by taking azithromycin. Before taking this medicine, you should not use Zithromax if you are allergic to azithromycin, or if: you have ever had jaundice or liver problems caused by taking Zithromax; or you are allergic to similar drugs such as clarithromycin, erythromycin, or telithromycin. To make sure Zithromax is safe for you, tell your doctor if you have ever had: liver disease; kidney disease; myasthenia gravis; a heart rhythm disorder; or low levels of potassium in your blood; or long QT syndrome (in you or a family member). Zithromax is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It zithromax chlamydia dose is not known whether azithromycin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Do not give Zithromax to a child younger than 6 months old. How should I take Zithromax? Take Zithromax exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. The dose and length of treatment with azithromycin may not be the same for every type of infection. Zithromax can be taken zithromax chlamydia dose with or without food. Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid zithromax chlamydia dose medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Zithromax will not treat a viral infection such as the flu or a common cold. Store at room temperature away from moisture and heat. Throw away any unused liquid medicine after 10 days. See also: Dosage Information (in more detail what happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line. What should I avoid while taking Zithromax? Do not take antacids that contain aluminum or magnesium within 2 hours before or after you take Zithromax.
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